Well, the USS Enterprise is captained by none other than the dashing legend Capt. James T. Kirk while the Star Destroyer might be captained by some inexperienced anonnymous poor bastard who hasn't yet been forced choked to death by Darth Vader for "failing him for the last time", so it's even if the Star Destroyer has a lot more firepower, it still wouldn't be a match. Put James T. Kirk and his crew aboard a Star Destroyer, give them some time to become familiar with it, and the Klingons, the Borg, the Centauri, the Empire, the Kardashians, the Gungans, the Cylons, the North Koreans, the Cardassians, the Vulcans, the Trade Federation, the sand people, the Mimbari, the Grays, the cockroaches, the Romulans, the Libyans, the Jedi, the humans, the Jawas, the Sith will all be banta fodder.
Yes, go have sex, I shall be right here debating this most important of topics.