Absolutely, without a doubt, one of the greatest guitar players to ever grace music...and truly a phenomenal songwriter.
Anyone that doesn't love Frank Zappa, can't possibly love there mom...or apple pie, or America.
Personally, I can't even begin to think about all of the great musicians he's worked with, but I do really like Jean Luc Ponty.
My favorite songs are probably "The Illinois Enema Bandit", from the "Live In New York" album, and "Magdalena", from "Just Another Band From L.A."