Besides being a musician, Keys is also an active philanthropist. She is a spokeswoman for Keep a Child Alive, a non-profit organization that provides life-saving AIDS medicines directly to children and families with HIV/AIDS in Africa. Keys and U2 lead singer Bono recorded a cover version of Peter Gabriel and Kate Bush's "Don't Give Up", in recognition of World AIDS Day 2006. Keys and Bono's version of the song has been retitled as "Don't Give Up (Africa)",[29] to show the two musicians' support for helping to raise awareness of people living with HIV and AIDS and acknowledging the twenty-five million Africans (forty million people worldwide) living with the disease. Cingular Wireless announced the debut of an exclusive Music Tone ringtone available only through the Cingular Sounds music program. One hundred percent of the proceeds from the ringtone sales will go to Keep a Child Alive.
Keys has visited African countries such as Uganda, Kenya, and South Africa[30][31] to promote care for children affected by AIDS. Keys, the global ambassador and co-founder of Keep a Child Alive, jet in on a four-day working visit in Masaka, Uganda on April 10, 2006 to bolster the HIV/AIDS crusade and give a ray of hope to families and children devastated by the scourge.[32] Keys visited sites funded by the organization "and brought footage home to the American public to encourage them to do more to help", according to a KACA statement. Throughout her visit, a film crew followed and documented the progress at both of these facilities for American news outlets.
Keys is also a spokewoman for Frum tha Ground Up, a charity devoted to inspiring, encouraging, and motivating American youths to achieve success on all levels. Keys also participated in other humanitarian efforts in 2005 by performing at several exclusive concerts and television shows. On July 2, Keys performed in Philadelphia, Pennsylvania, as part of the worldwide Live 8 concerts. The mission of the concerts was to raise awareness of the on-going poverty in Africa and to pressure the G8 leaders to take action by doubling aid, canceling debt, and delivering trade justice for Africa. In August 2005, Keys performed on ReAct Now: Music & Relief, a benefit program shown on music video channels to raise money for those affected by Hurricane Katrina. The following month, Keys performed at Shelter from the Storm: A Concert for the Gulf Coast, another Hurricane Katrina benefit concert.
Keys is an honorary member of the Alpha Kappa Alpha Sorority.